More and more scientific organisations, educational establishments and firms are joining forces as part of wide-ranging research and innovation strategies across Europe. Such initiatives require the injection of capital, so it is vital to assess the ROI (Return On Investment) for all concerned, as well as the potential economic repercussions of such business clusters for the regions where they are implanted. However, analysis of these projects cannot and should not stop there. A recent examination of a Grenoble-based collective highlights the crucial social and entrepreneurial impact that such a combining of expertise can have on a region. The numbers game is important, but does not paint the full picture. The pooling of scientific, academic and corporate expertise in a given area is known as a Territorial Innovation Model and may take a variety of forms, from industrial districts, and innovative milieus, to regional innovation systems, new industrial spaces, and regional clusters.